2,5-dicresol analysis gas chromatographMethod principle:2,5-dicresol is an important pharmaceutical and dye intermediate, and is the main raw material for the preparation of the new lipid-lowering drug gefitolozil. There have been no reports on its analytical methods, only a brief introduction to the spectra of phenolic substances in the literature. This article uses BCD quartz capillary column as the chromatographic column, FID is a detector that achieves faster and better separation through programmed heating, thereby improving analysis accuracy, shortening analysis time, and meeting the analysis requirements of industrial products.

Classic gas chromatography analysis spectrum

2,5-dicresol analysis gas chromatographoperation condition

Column temperature: initial temperature of 120 ℃, retention time of 19 min, final temperature of 220 ℃, retention time of 20 min, heating rate of 30 ℃/min; The temperature in the vaporization chamber is 250 ℃; Detector (FID) temperature 200 ℃, carrier gas (N2): 0.125 MPa, Separation ratio of 100:1, tail blowing 0 07 MPa; Injection volume: 0.1 LL.

Equipment configuration and reagents

GC-2020 gas chromatograph（Determination of 2,5-dicresol content）Performance characteristics

1. Adopting320 x 240dot matrix5.7An inch large screen LCD Chinese display, real-time display of various temperatures and operating conditions, clear and intuitive content, truly realizing human-machine dialogue;
2Power on self-test, wide range self diagnostic function, can accurately determine the fault location and alarm;
3Six independent temperature controls (vaporization chamber and capillary vaporization chamber can be independently controlled), Five level program heating function;
4Overtemperature Protection function: If any circuit exceeds the set temperature, the instrument will automatically power off and sound an alarm;
5The vertical heating device of * makes sample vaporization more reliable, reduces the heat radiation generated in the vaporization chamber to the minimum, and ensures minimal temperature deviation inside the column box;
6Intelligent fuzzy control rear door opening system, automatically tracks temperature and dynamically adjusts The angle of the air door can achieve precise temperature control even near room temperature;
7Configure filling column head injection, glass lining injection, with diaphragm cleaning Functional capillary diversion/Non split injection device and capable of installing gas injectors;
8High precision dual stable gas path, capable of installing four types of detectors simultaneously;
9Optional electronic flow pressure display system with built-in workstation device.

Temperature control indicators
1.Temperature control range: room temperature 5℃～400℃increment0.1℃
2.Temperature control accuracy: superior to±0.01℃

Program heating: Five step interval constant temperature time0～999minincrement0.1minTemperature increment0.1℃
Heating rate:200℃The biggest one below40℃/min200℃Up to the biggest20℃/min