• Product Name: 37370 Foot Tester
• Order number: tlyon000396
• Brand Name: Ugo Italy

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37370- Foot tester

The plantar tester is used to measure the response of rodents to infrared thermal stimulation. Focus the infrared light source on the bottom of the animal's foot, press the switch, wait for the animal to retract the test claw, and the instrument will automatically record the intensity and duration of the infrared light. The experimental data will be displayed on the LCD screen, and can also be imported into a USB drive or into a computer via a USB cable.

Although the pain tail flick and hot cold plate experiments are classic measurement methods for acute pain heat threshold, and these two experiments are still used in pharmacological research, they have some limitations. Both methods have not been applied in the study of behavioral responses to hyperalgesia.

Foot testing represents an advanced experimental method that combines the advantages of all pain allergy tests. During the experiment, the test animals will not be restrained; In addition, the experimental data recording is automatically sensed by the instrument and its accuracy will not be affected by personnel factors.

The latest model has a special filter that can cut off the visible spectrum, which can interfere with animal experiments and affect experimental results. If the experimental environment is incorrect, there is a feedback circuit that can detect experimental errors. Effectively avoid conducting experiments in the wrong environment.

The data is displayed on the front panel and can be transferred to the computer via USB. USB storage devices and software are included in the standard accessory package.

Recently, Ugo Basile launched the Durham rat restraint device, which can be used in conjunction with a foot tester and can also be used for testing trigeminal neuralgia in the lower jaw of rats

characteristic	advantage
The instrument automatically records the claw retraction time	There will be no errors caused by human factors
Equipped with USB interface and software included in the configuration	Can work independently or connect to a computer for use
The animal box can be adjusted appropriately (up to 12 mice can be accommodated)	Optimize the activity space of mice and rats based on their size

Specifications:

Comparison table of stimulation intensity values (infrared thermal radiation values) of plantar tester (unit: mW/cm2）

Stimulus Intensity	0	10	20	30	40	50	60	70	80	90	99
Standard radiation value	21±1	67±10	103±10	135±7	165±7	190±1	219±7	245±7	270±10	295±10	317±20

Command:	Soft key		Data transfer:	Equipped with flash memory
Data reading:	LCD screen display		Power Supply:	universal mains 85-264 VAC, 50-60Hz
Printing:	Thermal printer (to be purchased separately)		operation temperature	15° - 30° C
Start:	Infrared light source switch		Sound level:	< 70 dB
Infrared light intensity:	Adjustable between levels 01-99		Calibration:	Infrared Radiometer
Reaction time:	Displayed on the LCD screen; Resolution of 0.1s		Connect computer:	DELTA 9-pin connector Refer to instruction manual 3.5
Infrared light bulb: Specifications: Animal Cover: Net weight: Gross weight: Packaging specifications:	Halogen "Bellaphot", Mod. 64607 OSRAM, 8V-50W 85 x 40 x 35 cm 3, each 20x20x14 (h) cm 13.0kg About 27.5kg 109 x 53 x 55 cm

enclosure:

37300	Infrared thermal radiometer
57145	Micro printer
37000-145:	Panel embedded printer
37400-305: M-S 085: E-HR 002: 37370-278:	10 rolls of thermal printing paper (paper width 58 mm, paper roll diameter 30 mm) Replace the experimental cage Replace the light bulb Additional experimental components, including glass panels and animal restraints
37100	Rat restraint device for testing trigeminal neuralgia in the lower jaw

references

method

- D.C. Yeomans & H.K. Proudfit: “Characterization of the Foot Withdrawal Response to Noxious Radiant Heat in the Rat” Pain 59: 85-97, 1994.

- K.M. Hargreaves, R. Dubner, F. Brown, C. Flores and J. Joris: "A New and Sensitive Method for Measuring Thermal Nociception in Cutaneous Hyperalgesia." Pain 32: 77-88, 1988.

Literature mentioning UB products

- V. Vacca et alia: “Botulinum Toxin A Increases Analgesic Effects of Morphine, Counters Development of Morphine Tolerance and Modulates Glia Activation and μ Opioid Receptor Expression in Neuropathic Mice” Brain, Behav and Immunity 32: 40-50, 2013

- A. Finley et alia: “Sphingosine 1-Phosphate Mediates Hyperalgesia via a Neutrophil-Dependent Mechanism” PLoS ONE 8(1): e55255, 2013

- J. Donnerer et alia: “The Pain Pathway in the Rat following Noxious Thermal Stimulation: Effect of Morphine on pERK1/2 and TRPV1 at the Dorsal Horn Level, and on Hyperalgesia” Pharmacology 92: 32-38, 2013

- M. Arai et alia: “The miRNA and mRNA Changes in Rat Hippocampi after Chronic Constriction Injury”Pain Medicine 14 (5): 720-729, 2013

- P.J. Austin et alia: “G. Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats” JoVE 61, e3393, doi:10.3791/3393, 2012 http://www.jove.com/video/3393/chronic-constriction-sciatic-nerve-pain-hypersensitivity-testing

- H.N. Kim et alia: “Electroacupuncture Inhibits Phosphorylation of Spinal Phosphatidylinositol 3-kinase/Akt in a Carrageenan-induced Inflammatory Rat Model” Brain Res. Bulletin 87 (2-3): 199-204,2012

- D. Piomelli et alia: ”Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism” Nature NSC, 2010

- C.B. Vaegter et alia: ”Sortilin Associates with Trk Receptors to Enhance Anterograde Transport and Neurotrophin Signaling” Nature NSC, 2010

- O. Ortiz et alia: “Associative Learning and CA3–CA1 Synaptic Plasticity Are Impaired in D1R Null,Drd1a-/- Mice and in Hippocampal siRNA Silenced Drd1a Mice” J. Neuroscience 30 (37): 12288-12300,2010

- M. Rosemann et alia: “Microphthalmia, Parkinsonism, and Enhanced Nociception in Pitx3416insGMice” Mamm Genome 21: 12-27, 2010

- Mark J. Field et alia: “Detection of Static and Dynamic Components of Mechanical Allodynia in Rat Models of Neuropathic Pain: Are They Signalled by Distinct Primary Sensory Neurones?” Pain 83: 303-311, 1999

- Fred Lembeck: “Epibatine: High Potency and Broad Spectrum Activity on Neuronal and Neuromuscular Nicotinic Acetylcholine Receptors” Naunyn-Schmiedeberg’s Arch. Pharmacol. 359:378-385, 1999

- Hartmut Buerkle et alia: “Experimental Arthritis in the Rat Does Not Alter the Analgesic Potency of Intrathecal or Intraarticular Morphine” Anesth. Analg. 89: 403-408, 1999.

- F.G. Garrett, P.L. Durham et alia: “Validation of a Novel Rat-Holding Device for studying heat- and mechanical-Evoked Trigemi­nal Nocifensive Behavioral Responses” J. Orofacial Pain, 26 (4): 336- 344, 2012

- F.G. Garrett, P.L. Durham et alia: “Development of a novel device for measuring withdrawal latency by thermal stimulation in rodent facial pain models using the Hargreaves Plantar Apparatus” Poster presented at SFN 2010