Origin: Netherlands
What is Catwalk XT, an animal gait analysis system Why use an animal gait analysis system
It is a complete system for quantitative analysis of footsteps and gait in rodent models.
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A closed walkway can facilitate the assessment of the footprints and gait of non forced animals, obtaining a natural gait.
Illuminated Footprints ™ Technology captures the footprints of real dynamics.
Illuminated Footprints ™ Technology can achieve measurement of body weight distribution.
How does the animal gait analysis system work
The CatWalk XT animal gait analysis system is a complete system that includes software and hardware. It uses Illuminated Footprints ™ Technology captures every detail of every step. Save you a lot of experimental time through automatic footprint classification.
The core device of the animal gait analysis system is a closed walking platform where mice can walk from one end to the other. Footprint lighting technology enables the use of high-speed cameras to capture real footprints from below the walking platform.
Footprint lighting technology can even detect pressure differences, thereby measuring the distribution of animal weight on the four feet.
No mandatory measures were taken to maintain the natural gait of the animals. Walking speed is a very important factor in gait analysis. The gait analysis system can measure walking speed, select and analyze data. No need for external markings, nail trimming, excessive lighting, etc.
The measured parameters include landing time, hanging time, step size, pressure, distance between left and right feet, distance between front and rear footprints, step sequence, etc.
Who is suitable for using animal gait analysis systems
The following research areas can be evaluated using the animal gait analysis system CatWalk XT for injury, recovery, drug intervention, and other aspects.
Nerve injury
neurodegeneration
neurologic disease
Pain symptoms
spinal cord injury
Neuropathic Pain
arthritis
stroke
Parkinson's disease
ataxia
Traumatic Brain Injury (TBI)
Peripheral nerve injury
The latest version of the animal gait analysis system CatWalk XT9.0 adds new features
The latest version of the animal gait analysis system 9.0 has added interactive footprint measurement technology, which has taken the system a big step forward in automatic footprint analysis. The interactive footstep measurement function is a new extension module used to measure the distance between animal toe openings and paw orientation. In addition, new data segmentation techniques can help you obtain higher quality data every time animals cross the walking platform.
Interactive Footprint Measurement Function
The new interactive footprint measurement extension module can measure the following parameters:
• Distance from the opening of the distal toe end
• Distance of proximal toe opening
• Footprint length
• Claw orientation
The toe opening distance and footprint length are used to calculate the sciatic nerve function index. This index is used to evaluate the recovery of sciatic nerve function in rodents.
Data segmentation summary function
The Animal Gait Analysis System 9.0 provides a data segmentation summary function, allowing you to select animal walking segments based on speed parameters and the number of consecutive walks, thereby improving the quality of your experimental data and allowing you to control animal movement speed.
Add statistical parameters
In addition to the newly added footprint measurement parameter in the animal gait analysis system 9.0, it is used to calculate the sciatic nerve function index. In addition, the new parameters include: single foot support time, starting bipedal support time, and ending bipedal support time. These parameters are used to study the time required for single and double hind leg support of animals in pain experiments.
Automatic classification function for footprints
The animal gait analysis system includes automatic classification of footprints. Just press the button, and the system will automatically classify the footprints of animals during their walking process. If the system prompts for footprints that cannot be classified, the system will automatically highlight these footprints for you to manually mark. The preliminary test results were impressive: up to 70% of the time was saved in footprint classification, resulting in a 50% reduction in the overall experiment time. Absolutely worth the money!
In various animal models, the automatic classification technology of footprints has performed very well. Claw detection is very reliable, and most of the detection errors are due to stains on the walking platform. It is easy to identify erroneous fragments based on footprints and time views, allowing you to manually modify them. More than 90% of footprint classification does not require correction. For experimenters, footprint classification has also become an interesting job, "said Dr. Frankfurt from Sanofi Aventis pharmaceutical group in France.
Technical parameters:
references
The CatWalk gait analysis in assessment of both dynamic and static gait changes after adult rat sciatic nerve resection
R Deumens, RJP Jaken, MAE Marcus, EAJ … - Journal of neuroscience …, 2007 - Elsevier
Functional repair of neurotmesis has been proven most challenging in regenerative
medicine. Progress in this field has shown that functional repair not only requires axon
regeneration, but also selectivity in target reinnervation. Although selectivity in target ...
CatWalk gait analysis in assessment of functional recovery after sciatic nerve injury
A Bozkurt, R Deumens, J Scheffel, DM O'Dey, J … - Journal of neuroscience …, 2008 - Elsevier
Following peripheral nerve injury repair, improved behavioural outcome may be the most important
evidence of functionality of axon regeneration after any repair strategy. A range of behavioural
testing paradigms have been developed for peripheral nerve injury research. Complete ...
Automated quantitative gait analysis during overground locomotion in the rat: its application to spinal cord contusion and transection injuries
FPT Hamers, AJ Lankhorst, TJ van Laar, WB … - Journal of …, 2001 - liebertonline.com
... During a first automatic pass the bright areas in the individual frames are labeled and
in- dexed; in the subsequent pass, these spots are interactively CATWALK GAIT
ANALYSIS 189 Page 4. ... Page 5. CATWALK GAIT ANALYSIS 191 FIG. ...
CatWalk'automated quantitative gait analysis as a novel method to assess mechanical allodynia in the rat; a comparison with von Frey testing
DH Vrinten, FFT Hamers - Pain, 2003 - Elsevier
A characteristic symptom of neuropathic pain is mechanical allodynia. In animal models of neuropathic
pain, mechanical allodynia is often assessed using von Frey filaments. Although the forces applied
with these filaments are highly reproducible, there are various disadvantages of using this ...
CatWalk-assisted gait analysis in the assessment of spinal cord injury
FPT Hamers, GC Koopmans, EAJ … - Journal of …, 2006 - liebertonline.com
Gait analysis plays an important role in the assessment of neurological function in many disease
models. In this review, we focus on the newly developed CatWalk system for gait analysis. CatWalk
was originally developed as a tool to enhance assessment of functional outcome in spinal ...
The CatWalk method: Assessment of mechanical allodynia in experimental chronic pain
AF Gabriel, MAE Marcus, GHIM Walenkamp, … - Behavioural brain …, 2009 - Elsevier
... Available online 25 December 2008. Abstract. The CatWalk gait analysis system has recently
been suggested as a rapid and objective alternative method over the von Frey test to assess
mechanical allodynia in chronic neuropathic pain models. ...
Note: This product is mainly used as an experimental instrument for scientific research. Non clinical medical equipment.