Anipill ® Core body temperature capsule is a microcapsule that can continuously monitor, record, and wirelessly transmit core body temperature signals.

Applicable animals and usage: Small animals (rats and mice) can be implanted subcutaneously or intraperitoneally; Medium to large animals (such as beagle dogs, rabbits, pigs, etc.) can choose subcutaneous or intraperitoneal implantation, or be ingested into the body through the mouth, passed through the stomach and intestines, and finally excreted through the anus. Easy and convenient to use, widely used for monitoring core body temperature in small and medium to large animals.

ANIMALS MONITORING's animal core body temperature capsules include: Anipill capsules and Anilogger detectors.

Anipill capsules are used for implantation (or ingestion) into animals to collect their core body temperature; The capsule transmits the collected body temperature information to the Anilogger monitor through wireless signal transmission for display and reading. It is a non-invasive high-precision core body temperature collection device.

Applied in temperature regulation research, infectious diseases, biological rhythm analysis, animal dormancy, immune and vaccine development, toxicology research, etc. to strengthen temperature monitoring of experimental animals. It can continuously collect reliable and accurate core temperature data while maintaining normal physiological states such as comfort and mobility of small animals.

Anipill capsules are suitable for various animals, such as rats, mice, beagle dogs, rabbits, etc.

The main features of body temperature capsules are:

·The capsule has a compact size and can be taken orally (depending on the size of the animal) or implanted for use. It is easy to use and animal friendly;

·Wireless ductless measurement, and the test object does not need to wear a monitor in real time, achieving an unrestricted measurement solution;

·The monitor can simultaneously monitor data from 8 capsules and can connect up to 7 in parallel to achieve high-throughput measurement;

·The capsule has a built-in storage and memory function, which can store up to 2000 sets of data without worrying about data loss;

·Real time continuous core temperature monitoring based on telemetry technology.

Main technical parameters:

Measurement parameters: suitable for temperature range of 25-45 ℃, accuracy of 0.02 ℃, sampling frequency of 30Hz (adjustable), internal storage capacity of 2000 sets of data;

Transmission parameters: transmission distance of 1-3m, transmission frequency of 433Hz;

Service life: 20 days

Specification parameters: 17.7 * 8.9mm, weight 1.7g;

Can simultaneously monitor and display the transmission of capsules in 8 animals, and can be observed and analyzed through PC/MAC;

Each monitor can store 150185 sets of data;

Application 1: Research on Temperature Regulation

Four crab eating monkeys were implanted with capsules in their abdominal cavities, and then they were raised together with other unimplanted crab eating monkeys under standard conditions. Within the next week, measure body temperature every 15 minutes, and the experimental results are shown in the figure. This experiment demonstrates that the Anipill system can be used to continuously and reliably measure the body temperature of non-human primates, and the measurement results can clearly reflect the diurnal fluctuation pattern of crab eating macaques' body temperature.

Related literature:

· Laperrousaz et al., (2018) Lipoprotein Lipase Expression in Hypothalamus is involved in the Central Regulation of Thermogenesis and the Response to Cold Exposure

· Meyer et al., (2017) Body Temperature Measurements for Metabolic Phenotyping in Mice

· Rufiange et al., (2020) Pre-warming before general anesthesia with isoflurane delays the onset of hypothermia in rats

Application 2: Animal Physiology, Chronobiology, and Sleep Research

Data collected from capsules implanted into the peritoneum of non-human primates

Implant capsules into the abdominal cavity of rats, and after 7 days, monitor the changes in core body temperature of the following three groups of rats before and after anesthesia: preheat to 40 ℃ (PW40, n=17); Preheat to 1% above baseline body temperature (PW1%, n=17); No preheating (NW, n=17). This experiment demonstrates that preheating rats before anesthesia can help prevent hypothermia caused by anesthetics.

Related papers:

1.van der Vinne V, Pothecary C A, Wilcox S L, et al. Continuous and non-invasive thermography of mouse skin accurately describes core body temperature patterns, but not absolute core temperature[J]. Scientific Reports, 2020, 10(1): 20680.
2.Delezie J, Gill J F, Santos G, et al. PGC-1β-expressing POMC neurons mediate the effect of leptin on thermoregulation in the mouse[J]. Scientific Reports, 2020, 10(1): 1-12.
3.van der Vinne V, Tachinardi P, Riede S J, et al. Maximising survival by shifting the daily timing of activity[J]. Ecology letters, 2019, 22(12): 2097-2102.
4.Hong S H, Hong J H, Lahey M T, et al. A low-cost mouse cage warming system provides improved intra-ischemic and post-ischemic body temperature control–application for reducing variability in experimental stroke studies[J]. Journal of neuroscience methods, 2021, 360: 109228.
5.Belloch F B, Beltrán E, Venzala E, et al. Primary role for melatonin MT2 receptors in the regulation of anhedonia and circadian temperature rhythm[J]. European Neuropsychopharmacology, 2021, 44: 51-65.
6.Tabarean I V. Neurotensin induces hypothermia by activating both neuronal neurotensin receptor 1 and astrocytic neurotensin receptor 2 in the median preoptic nucleus[J]. Neuropharmacology, 2020, 171: 108069.
7.Fenzl A, Kulterer O C, Spirk K, et al. Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis[J]. Molecular metabolism, 2020, 42: 101088.

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