Microdialysis is a new technology for dynamic micro biochemical sampling from living organisms, which can be used on anesthetized or awake organisms. It has the characteristics of continuous sampling, dynamic observation, quantitative analysis, small sampling volume, and light tissue damage.

Main principle:
Place a micro probe with dialysis function in the sampled biological tissue, and use a very fine injection pump to push the solution to the probe to achieve dialysis exchange with the low molecular weight substance to be measured in the tissue. The exchanged dialysate is collected and further analyzed using high-performance liquid chromatography or other instruments.

Main features:
1. Time resolution, which can continuously track the changes in the levels of various compounds in the body over time.
2. Spatial resolution, instant sampling and measurement, can truly represent the concentration of the target compound at the sampling site. At the same time, inserting probes into different parts of the body can study the in vivo distribution of the target compound.
3. Provide free small molecule compounds that do not contain large molecular substances such as proteins. The sample can be directly used for determination without pretreatment because it does not contain large molecular substances such as proteins and enzymes. It is of great significance for drug research.
4. There is no need to euthanize animals or prepare tissue homogenates, which does not damage the integrity of the body, can maintain actual physiological conditions, eliminate the impact of tissue homogenization on metabolic research results caused by the destruction of cell compartments in traditional drug metabolism research, reduce the number of experimental animals, and obtain information about intermediate processes of drug metabolism. (Traditional methods for measuring metabolite concentrations in serum, urine, or feces can only understand the final products of metabolism, but cannot reflect intermediate processes)
5. Research on pharmacokinetics can collect a large number of samples from the same animal without losing body fluid volume, avoiding the impact of reduced blood volume after blood collection on drug distribution and elimination in traditional research methods. Its temporal resolution can make pharmacokinetic data more accurate.
6. The sample volume remains constant, and the concentration of each component in the sample remains basically unchanged, resulting in less non-specific adsorption of drugs by the membrane.
7. It will not be enzymatically hydrolyzed due to sampling at room temperature, improving sample stability and allowing for easy separation and determination.
8. Small damage, allowing for continuous sampling of multiple organs and sites within the same organ in conscious and freely moving animals, and the animals themselves forming blank controls, enabling accurate and timely grasp of intermediate dynamic information of drug metabolism.

Product composition:
1、 Microdialysis needle
The unique design of the tail of the microdialysis probe ensures that only the tail connection will detach when the probe is pulled by external force, so only the tail connection head needs to be plugged in without the need to reinsert the probe.

3、 Dialysis fluid collector

Note: This product is mainly used as an experimental instrument for scientific research. Non clinical medical equipment.