Fragility testerIt is used to check the brittleness and fragmentation of non coated tablets according to the requirements of the Chinese Pharmacopoeia

He is a specialized instrument for technical indicators such as physical strength, crushing strength, etc.Fragility is an important indicator reflecting the quality of tablets, which has a direct impact on the production, packaging, transportation, and other aspects of tablets. The CS-2 Fragility Tester is a specialized instrument for checking the fragility of tablets. It is fully functional, easy to operate, and its performance indicators fully comply with the relevant requirements of the Chinese Pharmacopoeia and the United States Pharmacopoeia. When the loading wheel of the instrument rotates, the sample inside the drum continuously rolls, rotates or slides under the action of the baffle, and repeatedly falls from the axis to the drum wall or other sample pieces that fall first, causing the sample to constantly experience friction, vibration and impact. After the specified time, take out the sample to observe the damage and accurately weigh it to calculate the weight loss percentage.

Fragility testerThe main features of the cylinder are: it is made of high-quality colorless transparent organic glass, which can be pre made at will

Set speed and number of turns parameters; Display preset and real-time values in a time-sharing manner; Fully automatic intelligent control of cylinder rotation speed

Two parameters: degree and number of rotations; High control accuracy; Control automation, automatic detection, automatic diagnosis, and self

Motion alarm

Number of turntable cylinders 2

The inner diameter of the turntable cylinder is Φ 286mm

The depth of the turntable cylinder is 39mm

The height of drug slip is 156mm

● Rotation speed range 25 revolutions per minute

● Rotation speed accuracy ± 1 RPM

● Rotation range of 100 turns

● Rotation accuracy ± 1 turn

Continuous working time greater than 24 hours

Inspection method

Take several pieces with a weight of 0.65g or less, so that the total weight is about 6.5g; Take 10 pieces if the weight is greater than 0.65g. Blow off the fallen powder with a hair dryer, weigh it accurately, place it in a cylinder, and rotate it 100 times. Remove the powder using the same method, weigh accurately, and ensure that the weight loss does not exceed 1%, and no broken, cracked, or crushed pieces are detected. This experiment is generally conducted only once. If the weight loss exceeds 1%, it can be retested twice. The average weight loss of three times should not exceed 1%, and no broken, cracked, or crushed pieces should be detected.

If the shape or size of the test sample causes the tablets to roll irregularly in the cylinder, the base of the cylinder can be adjusted to form an angle of about 10 ° with the tabletop. During the experiment, the tablets will no longer aggregate and can fall smoothly.

For formulations that are prone to water absorption, attention should be paid to preventing moisture absorption during operation (usually controlling relative humidity below 40%).