DMT in vitro microvascular pressure diameter measurement perfusion system, also known as pressure electromyogram recording system. The difference between this system and the in vitro microvascular perfusion system for tension measurement is that it involves inserting two glass tubes into both ends of the blood vessel and using a pressure control device to perfuse and pressurize the interior of the vessel, making it approach a normal physiological state. By using a microscope camera system and image analysis control software, real-time monitoring of parameters such as blood vessel wall thickness, diameter, and intravascular flow can be achieved. Other imaging observations or electrophysiological experiments can also be conducted.

Typical applications:

basic function Small vessel function, vessel diameter Vascular smooth muscle function vascular endothelial function Measurement of vascular wall tension and thickness Evaluation of local vascular reactions	Vasoactive mechanism Endothelial cells: endothelial release factor (NO), prostaglandins, and endothelial hyperpolarizing factor (EDHF) Smooth muscle: calcium, potassium, and other ion channels Blood vessels and intramural nerves: endogenous release of neurotransmitters	Pharmacology and drug therapy Quantify the treatment effects of ACE inhibitors, insulin, etc Receptor research, receptor localization or receptor description Research on the Effects and Relationship of Vasoactive Exciters and Blockers
physiological changes aging be pregnant convulsion	Pathology hypertension arteriosclerosis diabetes Ischemia, heart disease, heart failure Tumor and vascular regeneration Heart and lung diseases	More extended functions electrophysiology Fluorescence measurement of ions and other substances within blood vessels

1) 110P Pressure Myograph System (DMT110P vascular pressure diameter measuring instrument)
This system is mainly used for vascular and microvascular pharmacology research, conducting pharmacological vascular evaluation under approximate physiological conditions, monitoring vessel diameter, vessel wall thickness, vessel pressure, and longitudinal force. Drug reactions and peripheral nerve stimulation effects, as well as the relationship between pressure and diameter, can all be quantified. In addition, structural features such as vascular cross-sectional area can also be quantified. The two ends of the microvessel are fixed on the tiny empty tube in the glass. In the experiment, the pressure in the blood vessel is adjusted to the level of normal internal pressure. Continuously monitor the inner and outer diameters of blood vessels through a microscope at the bottom.

Features and advantages: The bottom can be equipped with Nikon or Zeiss microscopes for vascular observation; High quality and high-precision research equipment; Conduct research on blood vessels (larger than 60 microns) under approximate physiological conditions; Built in heating, ideal for pharmaceutical reactions with the ability to accumulate various curves; Can be used to study the pressure and flow rate during the inflow of luminol; Research on vascular fluorescence spectroscopy and expanded calcium imaging; The sample remains active for more than 24 hours; User defined video calibration for measuring internal and external diameter ranges; ● Allow standardization and improve integrity and repeatability when continuously measuring longitudinal tension

110P Product Introductiondownload

2) 111P Pressure Myograph System (DMT 111P vascular pressure diameter measuring instrument)
This system is mainly used for vascular and microvascular pharmacology research, conducting pharmacological vascular evaluation under approximate physiological conditions, monitoring vessel diameter, vessel wall thickness, vessel pressure, and longitudinal force. Drug reactions and peripheral nerve stimulation effects, as well as the relationship between pressure and diameter, can all be quantified. In addition, structural features such as vascular cross-sectional area can also be quantified. The two ends of the microvessel are fixed on the tiny empty tube in the glass. In the experiment, the pressure in the blood vessel is adjusted to the level of normal internal pressure. Continuously monitor the inner and outer diameters of blood vessels through a microscope at the bottom.

Features and advantages: High quality and high-precision research equipment; Conduct research on blood vessels (larger than 60 microns) under approximate physiological conditions; Built in heating, ideal for pharmaceutical reactions with the ability to accumulate various curves; Can be used to study the pressure and flow rate during the inflow of luminol; Expanded imaging research, such as calcium and fluorescence spectroscopy studies; The sample remains active for more than 24 hours; User defined video calibration for measuring internal and external diameter ranges; ● Allow standardization and improve integrity and repeatability when continuously measuring longitudinal tension

111P Product IntroductionDownload


3) 115 FP Pressure Myograph System for rapid freezing (DMT 115FP rapid freezing vascular pressure diameter measuring instrument)
This system is mainly used for molecular biology and morphological research that requires rapid freezing of blood vessels. The system allows for rapid freezing and fixation of intact compressed blood vessels within 1 second. In some experiments, it may be necessary to immediately freeze the blood vessel in its reactive pressure state for biochemical or molecular biology measurements. The pressurized state can also be fixed and preserved in form or measured for immunofluorescence structural proteins. Used for studying small blood vessels (diameter greater than 60um). Monitor vessel diameter and longitudinal force under approximate physiological conditions. Drug reactions, the effects of peripheral nerve stimulation, and the relationship between pressure and diameter can all be quantified. Further structural features such as vascular cross-sectional area can also be quantified. The two ends of the microvessel are fixed on the tiny empty tube in the glass. In the experiment, the pressure in the blood vessel is adjusted to the level of normal internal pressure. Continuous video monitoring of inner and outer diameters is achieved through a microscope at the bottom.

Features and advantages: High quality and high-precision research equipment; Conduct research on blood vessels (larger than 60 microns) under approximate physiological conditions; Built in heating, ideal for pharmaceutical reactions with the ability to accumulate various curves; Can be used to study the pressure and flow rate during the inflow of luminol; Expanded imaging research, such as calcium and fluorescence spectroscopy studies; The sample remains active for more than 24 hours; User defined video calibration for measuring internal and external diameter ranges; ● Allow standardization and improve integrity and repeatability when continuously measuring longitudinal tension

115FP Product Introductiondownload

4) 120CP Confocal Pressure Myograph System (DMT120CP Laser Confocal Pressure Diameter Measuring Instrument)
This system is used for laser confocal microscopy or other high imaging equipment, and can be used for intracellular research of intact smooth muscle and endothelial cells. It is possible to study the intracellular ion concentration in microvessels (diameter>60 μ m), such as the transport of calcium and fluorescent probe labels or proteins.

The conical open bath design allows for the use of high magnification/high numerical aperture inverted lenses, making it convenient to use. It also allows for direct immersion observation of confocal microscope lenses. Additionally, the top Myograph can be flipped open, which facilitates maintenance and simplifies the vascular binding process.

120CP Product Introductiondownload

Other related products:

In vitro vascular tension measurement system

Ex vivo tissue perfusion system

Ex vivo vascular culture perfusion system

Ex vivo tissue organ perfusion system

Note: This product is mainly used as an experimental instrument for scientific research. Non clinical medical equipment.