The latest generation of optical oximeters, with non-invasive measurement throughout the entire process, can be used for measuring pulse oximetry in small animals under conscious and free movement conditions. It is widely used in cardiovascular research, diabetes, hypertension, kidney disease and other fields.

Blood oxygen saturation (SpO2) is the percentage of oxygenated hemoglobin in the blood that is bound by oxygen to the total available hemoglobin volume, which is the concentration of blood oxygen in the blood. It is an important physiological parameter of the respiratory cycle. Blood oxygen saturation can reflect the health level of the animal's respiratory system and cardiovascular system, playing an important role in clinical animal disease prevention and diagnosis. It also has a wide range of applications in the study of heart, lung, blood, and vascular diseases or drug testing.

MouseOx ® The Plus pulse oximeter only requires one probe to monitor multiple parameters, with multiple types of sensors suitable for newborn rats to adult rats. It also has a magnetic resonance compatible sensor that provides monitoring of physiological indicators of small animals during magnetic resonance imaging. For the measurement of physiological parameters of small and large rats in a awake state, it is equipped with a professional awake activity cage, a rotating bracket and lever arm, a low torque slip ring, a low stress environment, and software with a dedicated awake mode, including enhanced filters and control algorithms, allowing the instrument to more accurately monitor the heart rate and saturation (Sp02) of small animals in a awake activity state Respiratory rate, respiratory amplitude, and pulse amplitude, as well as providing subject activity measurements, are beneficial for providing more accurate data. At the same time, a multi-channel data collector can be selected to monitor up to 8-16 animals simultaneously. Equipped with professional software, all physiological parameters of small animals can be displayed on the software. It can also be selected as an 8-channel data collector with a temperature signal monitoring interface. Combined with the software's temperature module, it allows researchers to connect temperature sensors to monitor the body temperature of small animals.

The software has standard mode and advanced mode, which can set parameter upper and lower limit alarms for monitoring abnormal physiological parameters of animals. The advanced mode can observe physiological parameter data waveforms in real time on the monitoring page. The software supports real-time data monitoring, data regression and export, and can observe and monitor animals for a long time.

All measurements are completed through a non-invasive sensor, which is accurate, convenient, and efficient.

Model: MouseOx Brand: Starr is currently testing mice under anesthesia

Advantages and Characteristics:

The traditional method for detecting blood oxygen saturation is to first collect blood, then use a blood gas analyzer for electrochemical analysis to measure the partial pressure of oxygen (PO2), and then calculate the blood oxygen concentration. This method is cumbersome, requires professional operation, and cannot be continuously tested. The non-invasive blood oxygen adopts PPG technology, which mainly detects the concentration changes of Hb and HbO2. It has a fast time response, can achieve dynamic real-time monitoring, is smaller in size, and the entire system is easy to move and clinically monitor. The two have a good linear relationship.

MouseOx ® The Plus pulse oximeter is the latest generation of optical oximeters, which uses non-invasive measurement throughout the entire process. Compared with traditional invasive measurement methods, it has high accuracy, good repeatability, and stability. With just one probe, it can monitor various parameters including pulse oximetry, and can monitor conscious animals under normal physiological activity.

• Non invasive blood oxygen measurement for mice, neonatal rats, and rats, monitoring heart rate range of 90~900 BPM
• It can non invasively measure up to 7 physiological parameters: pulse oximetry, heart rate, pulse frequency, pulse amplitude, respiratory rate, respiratory amplitude, and body temperature.
• The sensor positions can be selected based on the application and needs of the experiment, including sensors for the feet, thighs, neck, and throat
• Using photoelectric sensing technology to measure principles, it is suitable for measuring animal blood pressure in anesthesia, wakefulness, and MRI environments
• High throughput design, capable of monitoring up to 16 animals at once
• Output raw pulse waveform, which can be input into other data acquisition systems for data analysis
• Parameter alarm function. Set alarms while monitoring vital signs to ensure the safety of subjects
• There are two communication methods available, which can export data through a USB flash drive or connect to a computer for real-time control and data transmission
• Can be continuously monitored and repeatedly tested, with high accuracy, good repeatability and stability

Application areas:

MouseOx ® The Plus pulse oximeter has a wide range of applications in studying heart, lung, blood, and vascular diseases or drug testing. Currently widely used in the following areas:
Monitoring vital signs during animal surgery: ensuring appropriate anesthesia depth, preventing hypoxia during surgery, controlling respiratory volume while observing, and adjusting oxygen volume while observing

Translational medicine research: influenza, pneumonia, respiratory syncytial virus, and other acute respiratory diseases; Lung injury, lung cancer COPD、 Sleep apnea and other chronic respiratory diseases; Shock animal model; Stroke and brain injury; Hypertension, hypotension, and other cardiovascular diseases; Hypoxia&Inhalation Research; Monitoring vital signs during surgery, anesthesia status, and live imaging process; Pharmacology and Toxicology Research

There are multiple probes to choose from:

·According to experimental requirements: rat type probe and mouse type probe can be selected;

·According to the animal's state: the probe can be selected for continuous measurement of conscious activity state and anesthesia (or surgery) state measurement;

·According to the number of animals: there are multi-channel adapters to choose from, which can simultaneously detect the vital signs of multiple animals;

·According to the usage environment: non-magnetic probes suitable for nuclear magnetic environments can be selected;

Main functions:

·Intraoperative monitoring of small animal surgery (ensuring appropriate anesthesia depth and preventing hypoxia during surgery)

·A non-invasive sensor obtains multiple vital signals (arterial oxygen saturation, heart rate, respiratory rate, pulse amplitude, respiratory amplitude)

·Record of cardiopulmonary function parameters

·Output simulated data

Model specifications:

Anesthesia configuration
MouseOxPlus host and matching cables
Thigh sensor
Foot sensor
Temperature sensor (optional)
Advanced software (with key)

Clear configuration
MouseOxPlus host and matching cables
Fixed bracket for steering gear and balance arm
Mouse Neck Sensor
Rat neck sensor
Temperature sensor (optional)
Domestic sober activity cage
Advanced software (including product key)

Imported sober activity cage (optional according to demand)
Imported mouse awake activity cage
Imported conscious activity cage for rats

.

Verified accuracy:

The comparison between invasive blood gas sampling measurement results and non-invasive MouseOx measurement results shows that there is a good linear relationship between the two.

Pulse, blood oxygen, respiration and other cardiopulmonary monitoring parameters:

·Pulse frequency monitoring within the range of 90 to 900 BPM (beat per minute, BPM)

·Monitoring range of blood oxygen saturation: 0% to 100% arterial blood oxygen saturation;

·Blood oxygen saturation monitoring error:<1.5% across the entire monitoring range;

·Blood oxygen saturation monitoring response time: Real time reporting of arterial blood oxygen saturation, screen refresh 0.72 seconds after each heartbeat;

·Respiratory rate monitoring range: 25 to 450 times per minute;

·Monitoring reaction time: The respiratory rate is reported to the user every 1.7 seconds, and the mobile report value is the average of 10 breaths;

·Non traumatic monitoring of pulse filling to estimate changes in blood flow;

·Pulse monitoring range: microvessels with an inner diameter of 0 to 800 micrometers;

·Monitoring error:<2.4% across the entire monitoring range;

·Monitoring reaction time: Pulse filling degree is reported to the user in real-time. After each heartbeat, the screen refreshes 0.72 seconds to display all measured pulse filling degrees;

·Non traumatic monitoring of changes in animal respiratory amplitude;

·Respiratory amplitude monitoring range: 25 to 450 times per minute;

·Respiratory amplitude monitoring response time: The respiratory rate is reported to the user every 1.7 seconds, and the value of the mobile report is the average of 10 breaths;

Blood oxygen respiration data collector:

8-channel data collector

·Pulse, blood oxygen, and respiratory data measurement can be performed on 1-8 mice

Analog signal output module:

Paired with an analog signal output module for real-time output of analog heartbeats:

Multiple clock test probes are available for selection:

According to the needs, the neck probe used when the mouse is awake, the foot probe used when under anesthesia, and the thigh probe can be selected

Mouse leg blood oxygen probe

Mouse Neck Blood Oxygen Probe

Rat Foot Blood Oxygen Probe

Newborn rat blood oxygen probe

Magnetic resonance applicable modules and probes

The device is conducting long-term and continuous data collection on conscious and active rats

Measurement software:

Real time display of monitoring data, with diagnostic mode and quotation function, data can be stored in Text or Windaq format

Yuyan Instrument is owned by STARR Corporation in the United StatesAuthorized Chinese agentMouseox from Starr Corporation in the United States is a monitor specifically designed for mice and rats, capable of measuring parameters such as pulse oximetry, respiration, heart rate, pulse amplitude, respiratory amplitude, and body temperature. Please call us for more information!

reference:

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