Many useful and necessary parameters can reflect cardiac function, including minimum dP/dt, maximum dP/dt, Develop stress and cardiac output. However, only the pressure volume (PV) loop can accurately describe the pumping mechanism of the heart.
In the past 30 years, research on PV rings has gradually become the "gold standard" for studying myocardial contractility, compliance, myocardial energy, and other in vivo related functional parameters. (And in some in vitro situations).

Rodent pressure volume conduit
The Scisense pressure volume system provides an advanced approach to defining the cardiac phenotype of transgenic mice. Our catheter is the smallest product specification in measuring left ventricular pressure and volume simultaneously, and it is also the product that can minimize interference.

Our catheter can not only evaluate hemodynamic parameters and cardiac function, but also continuously measure left ventricular pressure and volume, and its size is only 1.2F. In addition, our sensors can be small enough to pass through the aortic valve or other lumen without the need for exhaust bubbles or flushing.
The P-V catheter is equipped with high-precision pressure sensors (0.39 mm diameter) and four electrode rings (0.37 mm diameter, 0.25 mm width). In this way, the size of these components does not experience any sudden increase in the front end of the catheter, and therefore will not hinder the surgical operation.
The electrode spacing of the catheter can meet the requirementsThe need for experiments on rats and miceThe available electrode segment length for mice is 4.5 millimeters (center to center). The available electrode segment length for rats is 9 millimeters. The distance between the outer electrode ring and the inner electrode ring of the two types of catheters is 0.5 millimeters.
All models have electrodes placed between pressure sensors. The pressure control unit used in the Scisense pressure conduit includes a signal collector and an amplification circuit to provide an analog pressure signal and output it to any third-party data acquisition system.

Typical applications:

• Hemodynamics • Myocardial infarction • Ischemia reperfusion injury • Hypertension • Cardiac contractile function • Molecular Cardiology • Cardiovascular reconstruction Valve mechanics

• TAC • diabetes • Oxidative stress • Vascular diseases • Gene therapy • Cardiac diastolic function • Cardiomyopathy • Stem cell therapy

You can choose your own cardiac cycle, and the selected cycle software can calculate a large number of pressure and volume parameters such as ESPVR, EDPVR, PRSW, etc

Measurable parameters:


Technical parameters of pressure capacity conduit:

Measurement Range	-50 to + 300 mmHg(temperature range: 32-42°C)
Sensitivity	10µV/V/mmHg or higher
Frequency Response	0 to >10 kHz
Gauge Excitation	Constant current
Stability Zero offset drift	< 6 mmHg/12 hours *
Signal Gain Factor	200

Pressure volume conduit controller
The pressure volume controller is specifically designed for Scisense miniature pressure volume conduits to control the recording of pressure and conductivity/volume signals. The analog output is a standard BNC interface, so it can output signals and record them in any standard third-party data acquisition system.

Model	FV892A
Pressure Output	1 Volt/100 mm Hg(other outputs available)
Power Supply External AC power	+/- 12 Vdc
Dimensions:(H x W x L)	16.8 cm (6.6”) X 22.6 cm (8.9") X6.9 cm (2.7")
Calibration Controls	10 position output switch
Catheter Connector	91 cm (36”) or 152 cm (60”) cables
Output Connector	BNC

Large animal pressure volume conduit
For medical technology companies, the challenge is to provide accurate, reliable, and minimally invasive tools to study PV rings in larger animals. Scisense offers a full range of catheter based sensors to meet the needs of the scientific community in this area. ours3F (rabbit), 5F (dog/sheep/pig) and 7F (dog/sheep/pig)The pressure volume catheter can provide scientists engaged in cardiac research with unique techniques to obtain almost any imaginable hemodynamic and systolic index related ventricular function parameter. All catheters can be inserted into the carotid or femoral artery with extremely small procedures.
These catheters have been extensively tested, validated, and certified by the most authoritative institutions for measuring pressure and conductivity.
Operating principle:
Each catheter has multiple annular electrodes and at least one pressure sensor. After the catheter is inserted into the heart, these circular electrodes can span the long axis of the entire ventricle. The catheter end electrode and catheter proximal electrode (ventricular top electrode and ventricular bottom electrode) generate a low current electric field in the blood, and each pair of intervention recording electrodes can record the conductivity of blood in various segments of the heart chamber.
The blood volume in the central cavity changes during the cardiac cycle, and the conductivity recorded by each pair of recording electrodes also changes accordingly. By substituting this value into the volume equation, a real-time segmental volume signal can be obtained. The total volume of the ventricle is the sum of the volumes of each segment. Our unique hardware system outputs an analog voltage corresponding to the capacity change for each segment. The software system performs basic hemodynamic analysis and complex pressure volume loop analysis on these signals.
(Baan's equation: V= I- (L 2)(G-Gp) ）

Application areas: ● Heart failure ● Cardiac hypertrophy ● Cardiovascular reconstruction ● Ischemia/reperfusion injury ● Cardiac arrest ● Stem cell research Pharmacology and Toxicology ● Cardiac resynchronization therapy Surgical intervention

The Scisense pressure volume catheter is compatible with most commercial pressure volume systems on the market

Note: This product is mainly used as an experimental instrument for scientific research. Non clinical medical equipment.