Whole body plethysmography (non-invasive lung function testing system) is used to measure various lung function parameters of animals in a conscious and unrestrained state. The system's simplicity, ease of use, speed, and large data output make it a favored research tool for foreign pharmaceutical companies' R&D institutions, mainly used for conducting coarse screening experiments in the development of new drugs such as asthma. Its indicator parameters can well reflect the airway hyperresponsiveness of animals to drugs, and are suitable for research that requires animals to breathe naturally and long-term tracking experiments.

Each body tracing box is equipped with atomization attack, temperature and humidity compensation interfaces, as well as water supply interfaces and gas sampling interfaces to meet various special research needs.

WBPThe main functions of a whole-body plethysmographworking principle:

WBP mainly detects the changes in "box flow" data caused by airflow changes caused by animal nasal airflow and chest and abdominal respiratory movements, and calculates various indicator parameters based on temperature, humidity, and pressure data.

Acetylcholine (Mch) or physiological saline (NS) is nebulized into the body tracking box through an atomizer. The changes in respiratory movement of animals in the box after inhaling the nebulized gas cause corresponding changes in pressure and flow output inside the box. The pressure sensor (flow sensor) connected to the body tracking box transmits the collected signals to the signal processing system, and converts them into respiratory dynamics indicators under the action of a signal amplifier.

The whole body plethysmography system can be connected to 6 individual plethysmography chambers simultaneously, and the corresponding sensors can synchronously transmit the changes in pressure and flow rate inside each chamber to the signal processing system for processing, thus enabling synchronous lung function testing for multiple experimental animals.

model: WBP

The Whole Body Volume Recorder for Small AnimalsMain features:

·Suitable for mice, rats, guinea pigs (can be customized for large animal types such as monkeys and beagle dogs)

·No surgery is required, the animal is in a state of conscious and free movement;

·Real time monitoring of tidal volume with multiple factor compensations (such as Epstein&Epstein, Drorbaugh&Fenn)

·The data results are not affected by the side effects of anesthesia and physical trauma;

·Real time environmental monitoring (pressure, temperature, humidity)

·Repeating experiments on the same animal for several months is an ideal way for long-term tracking research;

·Allow a single experiment to last for several hours to several days;

·It is a good choice for screening experiments as it can simultaneously test 6 animals;

·Can be administered via nebulization (aerosol attack);

·The experimental operation is simple and easy to carry out;

·Can be flexibly combined with other experimental equipment or methods

The main application directions of whole-body volume recorders are:

·Airway hyperreactivity models

·Late phase response (LPR) studies

·Chronic studies in chronic disease research

·Drug screening

·Toxicology

Analysis software:

Different adapters can be used to detect different animals:

To test more lung function parameters, you can choose:

multiparameterPulmonary function testing system

To detect airway resistance in small animals, you can choose:

Four channel airway resistance and lung compliance detection system

Related literature on non-invasive pulmonary function measurement devices for small animals:
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